The Laguna de Bay Region is endowed with rich natural resources. Laguna de Bay alone, is home to a variety of organisms that comprise its biodiversity pool. Of note are the 31 species of fishes belonging to 16 families and 19 genera, the most dominant and important species were Therapon plumbeus and Glossogobius giurus (white goby), 154 species of phytoplankton, 36 species of zooplankton, and 24 species of macrophytes. Other organisms thriving in the lake include different species of mollusks, crustaceans, and birds that feed on the lake's resources.
Commercially important fishes include white goby, mudfish, ayungin, milkfish, catfish, kanduli, the tilapias, common carp and plasalit (Glossogobius giurus, Ophicephalus striatus, Therapon plumbeus, Chanos chanos, Clarias sp, Anus rnanilensis, Tilapia mossambica, T. nilotica, Cyprinus carpio and Trichogaster sp). The freshwater prawn Macrobrachium sp is also harvested commercially. A wide variety of waterfowl occur, the common species including Ixobrychus sinensis, I. cinnamomeus, Ardea cinerea, Rallus mirificus (a species endemic to the Philippines), Porphyrio porphynio, Fulica ama, Himantopus himantopus and Sterna albitrons.
The biological resources of the lake abound with fishes, mollusks, crustaceans, plankton and macrophytes (water lilies). The lake yields fishes both from the fishpens and open fisheries that are being sold at markets in Metro Manila and surrounding areas of the lake. Crustaceans (shrimps) and mollusks (snails) declined in production in the lake. Snails are being harvested by the sudsud fishing gear that hauls this resource for feeds for the duck industry that also destroys aquatic plants in the lake.